top of page

Featured Paper

My Research 

Connexin 32

Connexin 32 is a member of the Beta-Connexins, the members of which are CO2 sensitive. In the case of Connexin 32, CO2 binds to the residue Lysine 124 via a labile covalent bond. This residue is flanked by a motif which directs it toward the lysine 104 residue. The binding of CO2 to K124 causes it to form a carbamate bridge with K104, biasing the channel to open. The role of Connexin 32 in the Peripheral Nervous system and also its gating are yet to be eludicated. This 32 KDa member of the connexin family is found abundantly in the liver but is also seen to be expressed in tissues ranging across the PNS and CNS. Connexin 32 localises to the myelinating Schwann cells of Peripheral Nerves and ganglia. Specifically in the the Schwann cells, Connexin 32 localises to the paranode, the period breaks / interuptions in the myelin, and the outer two layers of the myelin.  

2ZW3.gif

Sourced from: https://www.google.com/url?sa=i&url=https%3A%2F%2Fbrainstudy.info%2Fimages%2Fconnexins-simple-definition&psig=AOvVaw2ieJgXLkgYcJEGy84fBPZb&ust=1634211775565000&source=images&cd=vfe&ved=2ahUKEwit2J20p8fzAhXTwoUKHUCSCSQQr4kDegQIARAa

My Current Projects

My Current research is aimed at answering the fundamental questions surrounding Connexin 32 that remain to be solved. Specifically, I am researching the gating of Connexin 32 and how this may become faulty by advent of mutation, and how this may lead to pathology in CMTX. Currently I am utilizing mutagenesis to assess how the gating of Connexin 32 is altered when comparing the Wild-type and mutants (used to mimic CMTX). I feel as if this research is essential as leaning more about Connexin 32, results in learning more about CMTX. CMTX is an X-linked muscular dystrophy resulting form mutation in the GJB1 gene, encoding Connexin 32. 

​

If you wish to learn more about my research or have any interesting projects that could benefit from the inclusion of my research, feel free to contact me.

Never Miss a New Post.

Thanks for subscribing!

RECENT POSTS

ABOUT US

DSC01567 (1).JPG

Hi! I'm Jack, a Biological Science graduate completing a summer research project, sharing the process with you. This is also a place for us to communicate current science in a easily digestible manner.  My research and main area of interest is Neurobiology, making it the main focus of this blog.

Featured Posts
 

  • Facebook
  • Instagram
  • Twitter

SUBSCRIBE

Thanks for subscribing!

MY PICK
OF THE MONTH

LIVE WIRED.jpg

This book is a personal favorite! Eagleman writes in manner equally captivating to neuroscience novices or experts. This book explores the idea of neuroplastity, otherwise referred to by Eagleman as being 'livewired'. The narrative revolves around the use of examples making it engaging and accessible to many. One such such as how in blind people the occipital cortex, involved in visual processing, undergoes invasion from neighboring areas, acting to enhance other senses such as hearing and touch allowing these individuals to still effectively navigate the dangers of the world 

Contact
bottom of page