Connexin 32 is a member of the Beta-Connexins, the members of which are CO2 sensitive. In the case of Connexin 32, CO2 binds to the residue Lysine 124 via a labile covalent bond. This residue is flanked by a motif which directs it toward the lysine 104 residue. The binding of CO2 to K124 causes it to form a carbamate bridge with K104, biasing the channel to open. The role of Connexin 32 in the Peripheral Nervous system and also its gating are yet to be eludicated. This 32 KDa member of the connexin family is found abundantly in the liver but is also seen to be expressed in tissues ranging across the PNS and CNS. Connexin 32 localises to the myelinating Schwann cells of Peripheral Nerves and ganglia. Specifically in the the Schwann cells, Connexin 32 localises to the paranode, the period breaks / interuptions in the myelin, and the outer two layers of the myelin.